Explore our publications in peer reviewed journals
Oncology
Dysregulation of MYC-family proteins sensitizes cancers to NMT inhibition: identification of NMTi sensitivity and mechanism. Zhang J, Lueg GA, Faronato M, Poon E, Gorelic A, Grocin AG, Caamano-Gutierrez, Falciani F, Solari R, Carr R, Bell A, Bartlett E, Hutton J, Llorian-SopenaM, Chakravarty P, Brzezicha B, Janz M, Garnett MJ, Chesler L, Calado DP, Tate EW. Cancer Res. 2023. 83 (7_Supplement): 4871
N-Myristolytransferase (NMT) inhibitors as novel potent payloads for antibody drug conjugates. Carr R.A., Solari R, D’Arcy N, Tate EW, Walton J, Orafidya F. Cancer Res. 2023. 83 (7_Supplement): 2635
From foe to friend: In vivo reprogramming of tumor-associated macrophages to an anti-cancer phenotype by modulating N-myristoyltransferase activity. Kallemeijn WW, Spear S, Walton J, Bussi C, Soudy C, Flynn HR, Skehel M, Carling D, Solari R, McNeish IA, Tate EW. Cancer Res. 2023. 83 (7_Supplement): 439
N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells. Thinon E, Morales-Sanfrutos J, Mann DJ, Tate EW. ACS Chem Biol. 2016 Aug 19;11(8):2165-76
Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology. Demetriadou A, Morales-Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate EW, Drousiotou A, Petrou PP. J Cell Sci. 2017 Mar 1;130(5):903-915.
FSP1 is a glutathione-independent ferroptosis suppressor. Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Grocin AG, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O’Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M. Nature. 2019 Nov;575(7784):693-698.
N-myristoyltransferase biology and chemistry
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells. McHugh, D., Sun, B., Gutierrez-Muñoz, C., Hernández-González, F., Guiho , MMR., Duran, I., Pombo, J., Pietrocola, F., Birch, J., Kallemeijn, W.W., Khadayate, S., Dharmalingam, G., Vernia, S., Tate, E.W., Martínez-Barbera, JP., Withers ,DJ., Thomas, G.J., Serrano, M., Gil, J. Nat Cell Biol. 2023. Nov 27.
COPIng with senescence. Victorelli, S., Passos, J.F. News & Views. Nat Cell Biol. 2023. Nov 27.
Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation. Kallemeijn WW, Lanyon-Hogg T, Panyain N, Grocin AG, Ciepla P, Morales-Sanfrutos J, Tate EW. Nat Protoc 2021.Oct 27, 16; 5083–5122. doi: 10.1038/s41596-021-00601-6
Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion. Schlott AC, Knuepfer E, Green JL, Hobson P, Borg AJ, Morales-Sanfrutos J, Perrin AJ, Maclachlan C, Collinson LM, Snijders AP, Tate EW , Holder AA. PLOS BIOLOGY. 2021. Oct 25, doi:10.1371/journal.pbio.3001408
High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Dian C, Pérez-Dorado I, Rivière F, Asensio T, Legrand P, Ritzefeld M, Shen M, Cota E, Meinnel T, Tate EW, Giglione C. Nat Commun. 2020 Feb 28;11(1):1132.
Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes. Lanyon-Hogg T, Ritzefeld M, Sefer L, Bickel JK, Rudolf AF, Panyain N, Bineva-Todd G, Ocasio CA, O’Reilly N, Siebold C, Magee AI, Tate EW. Chem Sci. 2019 Jul 1;10(39):8995-9000
Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors. Schlott AC, Mayclin S, Reers AR, Coburn-Flynn O, Bell AS, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker BL, Chung CW, Myler PJ, Fidock DA, Tate EW, Holder AA. Cell Chem Biol. 2019 Jul 18;26(7):991-1000.e7. doi: 10.1016/j.chembiol.2019.03.015. Epub 2019 May 9.
Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases. Kallemeijn WW, Lueg GA, Faronato M, Hadavizadeh K, Goya Grocin A, Song OR, Howell M, Calado DP, Tate EW. Cell Chem Biol. 2019 Jun 20;26(6):892-900.e4
Whole Proteome Profiling of N-Myristoyltransferase Activity and Inhibition Using Sortase A. Goya Grocin A, Serwa RA, Morales Sanfrutos J, Ritzefeld M, Tate EW. Mol Cell Proteomics. 2019 Jan;18(1):115-126. doi: 10.1074/mcp.RA118.001043. Epub 2018 Oct 19.
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Pérez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedán A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, Leatherbarrow RJ, Tuthill TJ, Solari R, Tate EW. Nat Chem. 2018 Jun;10(6):599-606.
N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action. Schlott AC, Holder AA, Tate EW. ACS Infect Dis. 2018 Apr 13;4(4):449-457
Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase. Yu Z, Brannigan JA, Rangachari K, Heal WP, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Medchemcomm. 2015 Oct 8;6(10):1767-1772.
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase. Rackham MD, Yu Z, Brannigan JA, Heal WP, Paape D, Barker KV, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Medchemcomm. 2015 Oct 8;6(10):1761-1766.
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW. Nat Commun. 2014 Sep 26;5:4919.
Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors. Hutton JA, Goncalves V, Brannigan JA, Paape D, Wright MH, Waugh TM, Roberts SM, Bell AS, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. J Med Chem. 2014 Oct 23;57(20):8664-70.
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW. Nat Chem. 2014 Feb;6(2):112-21.
