Our NMT Target
Myristoylation is a lipid modification involving the addition of myristic acid, a 14-carbon fatty acid, to the N-terminus of proteins. Catalysed by two enzymes, NMT1 and NMT2, this modification can occur co- or post-translationally. Approx. 1% of proteins in the human genome, which equates to ~150 proteins, are modified by NMT.
Inhibition of NMT is selective and highly efficacious in cancer cells.